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Midazolam의 비강내투여에 의한 진정요법
SEDATION THERAPY THROUGH INTRANASAL ADMINISTRATION OF MIDAZOLAM

대한소아치과학회지 1995년 22권 2호 p.481 ~ 485

고명연, 김지현,

소속 상세정보

고명연 ( ) - 부산대학교 치과대학 소아치과학교실
김지현 ( ) - 부산대학교 치과대학 소아치과학교실

KMID : 0358919950220020481

Abstract

결론
비협조적인 어린이는 치료의 어려움 뿐 아니라 향후 치료에 대한 부정적 인식을 가질 수
있다. midasolam의 비강내 투여에 의한 진정요법은 비교적 최근에 도입된 방법으로써 임상
적, 실험적 연구에 의해 뒷받침되는 소아치과 영역에 적합한 약제이다. 저자는 본원에 내원
한 비협조적인 행동을 보이는 어린이 수 명을 대상으로 midasolam의 비강내 투여에 의한
진정요법을 적용하여 관찰한 결과 다음과 같은 결론을 얻었다.
1. 70% 정도의 환아에서 10 분내에 주목할 정도의 진정효과가 관찰되었다.
2. 치과적 자극 때문에 약간의 용량 증가가 필요한 경우도 있었다.
3. 여타의 투여 경로에 비해 환아의 불편이나 거부감이 적었다.
4. 환아가 완전히 잠이 드는 경우는 드물었으며 대부분 drowsy나 calm한 상태였다.
5. 치과시술에 적합한 정도의 진정시간이 유지되었다.
6. 다른 약제의 부가적 사용도 유용하였다.
7. 과용량이나 부작용은 관찰되지 않았다.
#초록#
Various methods have been attempted for behavioral control of uncooperative children
in the field of pediatric dentistry. Uncooperative children is not only difficult to treat but
there is also a tendency to provoke negative attitude for further dental treatment.
Therefore the importance of sedative therapy by drug is unquestionable.
Many drugs are being used for behavioral control. Midazolam, synthesized by Fryer &
Walser in 1976, has outstanding characteristics and is widely used for behavioral control
of uncooperative children. It's onset time is rapid and due to rapid metabolism, it has
short acting time. Its low toxicity renders broad range of use in treatment and
manifests and profound sleep and sedation which makes it an useful drug for behavioral
control of uncooperative children in dentistry.
There are various routes of administration, but by intranasal method, the direct
absorption rapid, rate of metabolism is reduced and is technically easy.
Some children who were uncooperative were chosen among the patients who visited
our department and the following results were obtained by attempting to induce sedation
with intranasal administration of midazolam.
1. Remarkable sedative effect was observed within 10 min. in most case. (about 70%)
2. In some cases, higher dosage adjustment was required.
3. Less patient discomfort & rejection was found compared with other routes.
4. Only a few fell asleep completely, whereas most became drowsy or calm.
5. Duration was sufficient for most dental treatment.
6. Comedication was thought desirable.
7. Any adverse reaction or complication was not observed.